Topics in Nucleic Acid Structure

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Structural Biochemistry/Nucleic Acid/DNA/DNA structure

Deoxyribonucleic acid (DNA) stores information for the synthesis of specific proteins. DNA has deoxyribose as its sugar. DNA consists of a phosphate group, a sugar, and a nitrogenous base. The structure of DNA is a helical, double-stranded macromolecule with bases projecting into the interior of the molecule. These two strands are always complementary in sequence. One strand serves as a templat...

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The Structure of Yeast Nucleic Acid

The tetranucleotide theory of the structure of yeast nucleic acid was first enunciated by the writer1 and was subsequently conclusively demonstrated by the experimental evidence furnished by Levene and Jacobs,2 ‘and by Levene and La Forge.3 The facts on which the theory was based were: first, the isolation of four nucleosides; second, the isolation of simple pyrimidine nucleotides. These were o...

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A structure for deoxyribose nucleic acid.

A structure for nucleic acid has already been proposed by Pauling and Corey (1). They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fibre axis, and the bases on the outside. In our opinion, this structure is unsatisfactory for two reasons: (1) We believe that the material which gives the X-r...

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Chemical etiology of nucleic acid structure.

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

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The Structure of Yeast Nucleic Acid

Levene and Jacobs have formulated the structure of yeast nucleic acid as a tetranucleotide. The facts that led up to their formulation were: 1. The formation of four nucleosides on neutral or ammonia hydrolysis. 2. The formation of simpler nucleotides on hydrolysis with dilute mineral acids. 3. The presence of a phosphorus to nitrogen ratio which agreed quite well for t.he tetranucleotide theor...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1982

ISSN: 0014-5793

DOI: 10.1016/0014-5793(82)81268-4